2018骞�8鏈�锛屽寳浜�鐢熷懡绉戝��(xu茅)鐮旂┒鎵�鍓�鎵�闀烽偟宄伴櫌澹�鍦�(tu谩n)闅�(du矛)鍦ㄣ��Nature銆嬩笂鐧�(f膩)琛ㄤ簡椤岀偤銆�Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose銆嬬殑鐮旂┒璜栨枃锛岄�栨�¤瓑鏄�浜岀７閰歌吅鑻峰簹绯�锛�ADP-heptose锛夊彲浣滅偤鐪熸�ｇ殑鐥呭師鐩搁��(gu膩n)妯″紡鍒嗗瓙(PAMP)锛岄�忛亷鍝轰钩鍕�(d貌ng)鐗╃殑绱�(x矛)鑳炶啘锛岃��浣滅偤妯″紡璀�(sh铆)鍒ュ彈楂�(PRR)鐨勬柊鍨嬪厤鐤�鍙楅珨婵�閰�ALPK1鎵�璀�(sh铆)鍒�锛屾縺娲�NF-κB閫氳矾浠嬪皫(d菐o)鐨勫ぉ鐒跺厤鐤�鐐庣櫏鍙嶆��(y墨ng)銆�^[1]

ADP-heptose鏄�绱�(x矛)鑿岃剛澶氱硸(LPS)鍚堟垚閬庣▼涓�鐨勫墠楂斾唬璎濈��(ch菐n)鐗�锛屽瓨鍦ㄤ簬鎵�鏈夐潻铇�姘忛櫚鎬ц弻鍜岄儴鍒嗛潻铇�姘忛櫧鎬ц弻涓�銆傚墠鏈熺爺绌惰〃鏄庯紝搴氱硸-1,7-浜岀７閰革紙Heptose 1,7-bisphosphate, HBP锛変笉鍏锋湁鑷�涓婚��(j矛n)鍏ュ�夸富绱�(x矛)鑳炵殑鑳藉姏锛屼篃涓嶈兘鐩存帴婵�娲�ALPK1锛屽彧鑳藉湪绱�(x矛)鑳炲収(n猫i)浠ｈ瑵鐐轰簩纾烽吀鑵鸿嫹搴氱硸-7-纾烽吀锛�ADP-heptose 7-P锛夋柟鍙�婵�娲�ALPK1銆傜浉姣�HBP锛�ADP-heptose鍙�浠ヨ嚜涓婚��(j矛n)鍏ュ�夸富绱�(x矛)鑳�锛屾縺娲�ALPK1锛屼笖娲绘�ч仩(yu菐n)閬�(yu菐n)楂樹簬HBP锛堝湒1锛�銆�ADP-heptose-ALPK1澶╃劧鍏嶇柅淇¤櫉(h脿o)閫氳矾鍦ㄦ姷寰＄窗(x矛)鑿屾劅鏌撻亷绋嬩腑鐧�(f膩)鎻�閲嶈�佷綔鐢�锛岄�欎竴鍏ㄦ柊閫氳矾鐐虹浉闂�(gu膩n)鐤剧梾鐨勮棩鐗╃爺鐧�(f膩)鎻愪緵浜嗛澏榛�(di菐n)銆�^[1]

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鈻�  鐢�(ch菐n)鍝佸劒(y艒u)鍕�锛�

• 鍏ㄦ柊鐥呭師鐩搁棞(gu膩n)妯″紡鍒嗗瓙(PAMP)锛岃��鏂板瀷鍏嶇柅鍙楅珨婵�閰�ALPK1璀�(sh铆)鍒�锛屾縺娲诲�夸富澶╃劧鍏嶇柅鍙嶆��(y墨ng)锛屾椿鎬ч仩(yu菐n)閬�(yu菐n)楂樹簬HBP锛岀偤澶╃劧鍏嶇柅闋�(l菒ng)鍩熺�戠爺宸ヤ綔鑰呮彁渚涚爺绌舵柊鎬濊矾锛堝湒1锛�
• 鐛�(d煤)瀹朵笖鐝�(xi脿n)璨ㄤ緵鎳�(y墨ng)姝ょ敘(ch菐n)鍝�

鍦�1 ADP-heptose鑸�HBP婵�娲荤啋鍏夌礌閰舵椿鎬у皪姣�^[1]

鈻�  鐢�(ch菐n)鍝佷俊鎭�  

鈻�  鐩搁棞(gu膩n)鐢�(ch菐n)鍝佸拰鑰楁潗 

鍙冭�冩枃鐛�(xi脿n)

[1] Zhou, P., et al. Nature. 2018, 561(7721): 122-126.