涓夋盁鐢插熀鏄�涓�绋�閲嶈�佺殑绲愭�嬶紝灏囧叾寮曞叆鍒版湁姗熷寲鍚堢墿涓�鑳戒娇鐩�妯欑敘鐗╃殑妤垫��銆佸伓妤电煩銆佺┅(w臎n)瀹氭��銆佽Κ鑴傛�у緱鍒版彁楂�锛屽洜姝ゅ惈涓夋盁鐢插熀鐨勫寲鍚堢墿鍦ㄩ啱(y墨)钘�銆佽静钘ャ�佹柊鍨嬫潗鏂欑瓑闋樺煙鏈夐噸瑕佺殑鎰忕京銆傛盁纾�?锛涱姧顟绢尅瀹滃硳鏌炪偅顭囨悡鎰掑櫗?锛�Chen’s reagent^[1]锛夋槸寤ｇ偤鎳夌敤鐨勭稉婵熼珮鏁堢殑涓夋盁鐢插熀鍖栬│鍔�锛岄�氶亷瑭茶│鍔戝�︾��(xi脿n)浜嗙��涓�渚嬫湁姗熼沟浠ｇ墿鐨勫偓鍖栦笁姘熺敳鍩哄寲鍙嶆噳銆�

                                                                鍦�1 闄虫皬鏂规硶瀛告盁鐑峰熀鍖栬│鍔�

[1] Clarke S L, Mcglacken G P. Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation[J]. Chemistry - A European Journal, 2017, 23(6):1219-1230.

[2] Zhao G, Wu H, Xiao Z, et al. Trifluoromethylation of haloarenes with a new trifluoro-methylating reagent Cu(O₂CCF₂SO₂F)₂[J]. Rsc Advances, 2016, 6(55):50250-50254.

[3] Liu Y G, Wu H, Guo Y, et al. Trifluoromethylfluorosulfonylation of Unactivated Alkenes Using Readily Available Ag(O₂CCF₂SO₂F) and N鈥�Fluorobenzenesulfonimide[J]. Angewandte Chemie International Edition, 2017, 56(48):15432-15435.

鐧鹃潏濞佷綔鐐哄皥妤�(y猫)鐨勮│鍔戜緵鎳夊晢锛屾帹“闄�”鍑�“鏂�”锛屾彁渚涙柊鍨嬮櫝瑭﹀姂^{[2, 3]}锛�

1. Cu(O₂CCF₂SO₂F)₂

• 鍩轰簬闄宠│鍔戦枊鐧�(f膩)鍑虹殑鏂颁竴浠ｄ笁姘熺敳鍩哄寲瑭﹀姂锛�
• 鍙嶆噳婧�鍜岋細鍌崇��(t菕ng)闄宠│鍔戝弽鎳夐渶瑕佷竴瀹氱殑婧�搴�锛屾�ら妳楣藉�ゆ韩鍗冲彲鍙嶆噳锛�
• 鎳夌敤鏇村唬銆佹洿楂樻晥锛氳姵棣欑挵(hu谩n)銆侀洔鐠�(hu谩n)銆�SP3閸电祼妲嬪潎鍙�鎳夌敤锛�
• 鍙嶆噳娲绘�ч珮锛屾晥鐜囬珮銆�

鐢㈠搧绶ㄨ櫉	鐢㈠搧鍚嶇ū	绲愭�嬪��	CAS	鍖呰��
2763569	Fluorosulfonyldifluoroacetic acid copper(II) salt, 98% 姘熺牅鍩轰簩姘熶箼閰搁妳, 98%		1629684-53-2	10G

2. Ag(O₂CCF₂SO₂F)

• 灏囬櫝姘忔柟娉曞�镐笁姘熺敳鍩哄寲瑭﹀姂鎳夌敤鑼冨湇棣栨�℃摯澶у埌鑷�鐢卞熀涓夋盁鐢插熀鍖栧弽鎳�锛�
• 鍏呭垎鍒╃敤浜嗗壇鐢㈢墿浜屾哀鍖栫～锛屽皣鍏惰綁鍖栫偤閲嶈�佺殑纾洪叞姘熷熀鍦橈��
• 棣栨�″悓鏅傚悜鍒嗗瓙涓�寮曞叆涓夋盁鐢插熀鍜屾盁纾�?锛�?銆�
  

3. 鍏朵粬涓夋盁鐢插熀鍖栬│鍔�

鐢㈠搧绶ㄨ櫉	鐢㈠搧鍚嶇ū	绲愭�嬪��	CAS	鍖呰��
376697	2-Chloro-4-(trifluoromethoxy)aniline, 95% 2-姘�-4-(涓夋盁鐢叉哀鍩�)鑻�鑳�, 95%		69695-61-0	1G 5G
221472	Lithium bis(trifluoromethanesulfonyl)imide, 99% 闆�(涓夋盁鐢茬：閰�)浜炶兒閶�, 99%		90076-65-6	10G 50G 250G
210460	Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate, 98% 2,2,-浜屾盁-2-姘熺：閰颁箼閰哥敳閰�, 98%	銆�	680-15-9	5G 25G
400298	Sodium trifluoromethanesulfonate, 98% 涓夋盁鐢茬：閰搁垑, 98%		2926-30-9	5G 25G
244874	Trifluoromethanesulfonic anhydride, 98% 涓夋盁鐢茬：閰搁厫, 98%		358-23-6	10G 50G
432354	Trifluoromethanesulfonimide, 99% 涓夋盁鐢插熀纾洪叞浜炶兒, 99%		82113-65-3	1G 5G 25G
207732	4-(Trifluoromethyl)benzaldehyde, 98% 4-(涓夋盁鐢插熀)鑻�鐢查��, 98%		455-19-6	5G 25G
582061	4-(Trifluoromethylthio)bromobenzene, 97% 4-(涓夋盁鐢茬～鍩�)婧磋嫰, 97%		333-47-1	1G 5G

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