浜岀７閰歌吅鑻峰簹绯栵紙ADP-Heptose锛夋槸绱�(x矛)鑿岃剛澶氱硸(LPS)鍚堟垚閬�(gu貌)绋嬩腑鐨勫墠楂斾唬璎濈敘(ch菐n)鐗╋紝瀛樺湪浜庢墍鏈夐潻铇皬闄版�ц弻鍜岄儴鍒嗛潻铇皬闄�(y谩ng)鎬ц弻涓�銆�2018骞�锛� ADP-Heptose琚瀛�(xu茅)瀹堕娆＄郴绲�(t菕ng)璀夋槑鍙綔鐐虹湡姝ｇ殑PAMP锛岄�忛亷(gu貌)鍝轰钩鍕�(d貌ng)鐗╃殑绱�(x矛)鑳炶啘锛岃浣滅偤PRR鐨勫唬娉涜〃閬�(d谩)鐨�ALPK1婵�閰惰瓨(sh铆)鍒�锛屾縺娲�NF-κB閫氳矾浠嬪皫(d菐o)鐨勭窗(x矛)鑳炲洜瀛愬拰鐐庣櫏鍥犲瓙鐨勭敘(ch菐n)鐢熴��鍥犳锛�ADP-Heptose鎿佹湁宸ㄥぇ鐨勭殑甯傚牬(ch菐ng)鎳�(y墨ng)鐢ㄦ經鍔�锛屽鐢ㄤ綔鍏嶇柅瑾�(di脿o)绡�(ji茅)鍔戝拰鐤嫍浣愬姂绛�[1]銆�
鐧鹃潏濞佷綔鎻愪緵ADP-Heptose鐢�(ch菐n)鍝�锛屽唬娉涚敤浜庤灏忔澘婵�娲绘(j墨)鍒躲�佹姉琛�灏忔澘钘ヤ綔鐢ㄦ(j墨)鐞嗙殑鏂拌棩鐮旂櫦(f膩)銆佽灏忔澘鐩搁棞(gu膩n)鎬х柧鐥呯殑鐧�(f膩)鐥呮(j墨)鍒跺強闃叉不绛夌浉闂�(gu膩n)鐮旂┒銆�
- 鏂扮⿴鎬у挤(qi谩ng)锛屽姪鍔涢啱(y墨)鐧傘�佹姉鑿岃棩鐗╂柊闋�(xi脿ng)鐩爺鐧�(f膩)锛�
- 绯诲垪瀹屾暣锛岄嚌灏�(du矛)鎬у挤(qi谩ng)锛岄仼鍚堢閬告柊闈堕粸(di菐n)鐨勫(sh铆)椹�(y脿n)瑷�(sh猫)瑷�(j矛)銆�
浜岀７閰歌吅鑻峰簹绯�(ADP-heptose)
鐢�(ch菐n)鍝佺法铏�(h脿o)锛�9020852
鍙冭�冩枃鐛�(xi脿n)锛�
[1] Zhou, P., et al. (2018). "Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose." Nature 561(7721): 122-126.
鈻� 鐢�(ch菐n)鍝�鍒楄〃
|
鐢�(ch菐n)鍝佺法铏�(h脿o)
|
鐢�(ch菐n)鍝佸悕绋�
|
CAS铏�(h脿o)
|
绱斿害
|
鍖呰
|
|
9020852
|
ADP-heptose
浜岀７閰歌吅鑻峰簹绯�
|
N/A
|
95%
|
1mg
|
|
996513
|
β-Propiolactone, 98%, research grade ,
β-涓欏収(n猫i)閰�, 瑭﹀姂绱�(j铆)
|
57-57-8
|
98%
|
5ML
25ML
|
|
563051
|
D-(+)-Trehalose dihydrate, 99% ,
D-(+)-娴疯椈绯栦簩姘村悎鐗�
|
6138-23-4
|
99%
|
5g
25g
100g
500g
|
|
387160
|
L-Glutathione, 99%, for analysis, reduced ,
L-璋疯儽鐢樿偨, 鐢ㄤ簬鍒嗘瀽, 閭勫師鍨�
|
70-18-8
|
99%
|
1g
5g
25g
100g
|
|
917079
|
Guanidine hydrochloride, 99% ,
楣介吀鑳�
|
50-01-1
|
99%
|
25g
100g
500g
|
|
226396
|
Formaldehyde, 37% solution in H2O, stabilized with MeOH ,
鐢查啗, 37% 姘存憾娑�, 鍚┅(w臎n)瀹氬姂
|
50-00-0
|
N/A
|
500ML
1L
|
|
926470
|
Dithiothreitol, 99%, for molecular biology ,
浜岀～铇囩硸閱�, 鐢ㄤ簬鍒嗗瓙鐢熺墿瀛�(xu茅)
|
3483-12-3
|
99%
|
1g
5g
|
|
403474
|
Sodium cholate, 98% ,
鑶介吀閳�
|
361-09-1
|
98%
|
5g
100g
|
|
993361
|
Triton X-100, 98%, for molecular biology ,
鏇叉媺閫� X-100, 鐢ㄤ簬鍒嗗瓙鐢熺墿瀛�(xu茅)
|
9002-93-1
|
98%
|
100ML
250ML
500ML
1L
|
鈻� 鏈牁(l菒ng)鍩熼�氱敤鐢�(ch菐n)鍝佺郴鍒�