甯剁敳鍩哄伌(c猫)閺�?zh菙n)涓牻鍣敠涓旀椿鎰嬫沪瑜腑闄㈤摚绋嶅櫗?锛屽唬娉涘瓨鍦ㄤ簬鍏锋湁鐢熺墿娲绘�х殑澶╃劧鐢�(ch菐n)鐗╁垎瀛愪腑锛屽付鐢插熀鍋�(c猫)閺�?zh菙n)涓牻鍣敍鍟嗗ú榉ら箻y(t菕ng)鐨勯鑼呴啗/棣欒寘閱囬鐨勬墜鎬ц│鍔�锛屾槸鍚堟垚鍏锋湁鐗规畩鐢熺墿娲绘�х殑澶╃劧鐢�(ch菐n)鐗╁拰钘ョ墿鍒嗗瓙鐨勯噸瑕佹墜鎬у師鏂欙紝濡傛姉鑵槫椤為啱(y墨)钘1,2]銆佺兢鏌辫煵鍏�(n猫i)閰疌lavulactone鍙婂叾椤炰技鐗3]銆佹槅锜插瀷淇℃伅绱燵4,5,6]銆侀鏂欑瓑锛屾槸杩戝勾渚嗘瘮杓冪啽闁�鐨勪竴椤炴墜鎬у悎鎴愯│鍔�銆�
鐧鹃潏濞佸彲鎻愪緵鍏ㄦ柊甯剁敳鍩哄伌(c猫)閺�?zh菙n)涓牻鍣攰a(ch菐n)鍝侊紝鍖栧(xu茅)绱斿害鍙婂厜瀛�(xu茅)绱斿害楂�锛岀従(xi脿n)璨ㄤ緵鎳�(y墨ng)锛屽姪鍔涢啱(y墨)钘�銆侀鏂欏悎鎴愬寲瀛�(xu茅)瀹跺揩閫�銆佹湁鏁堝湴瑙ｆ焙鍏锋湁鐗规畩鐢熺悊娲绘�уぉ鐒跺京(f霉)闆滃垎瀛愬収(n猫i)澶氬��(g猫)鎵嬫�ф(g貌u)绛戠殑澶ч洠椤�锛�
|
鐢�(ch菐n)鍝佺法铏�(h脿o)
|
鐢�(ch菐n)鍝佸悕绋�
|
绲�(ji茅)妲�(g貌u)寮�
|
瑕�(gu墨)鏍�
|
CAS
|
|
|
(R)-3-((R)-2,2-浜岀敳鍩�-1,3-浜屾哀浜旂挵(hu谩n)-4-鍩�)-2-鐢插熀-1-涓欓唶
(R)-3-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2-methylpropan-1-ol
95% [ee: 98%]
|
|
1 g
5 g
|
|
|
|
(R)-5-鑺愭哀鍩�-4-鐢插熀-2-姘�-鎴婇吀鐢查叝
(R)-5-Benzyloxy-4-methyl-2-oxo-methyl pentanoate
95% [ee: 98%]
|
|
1 g
5 g
|
|
|
|
(R)-4-鑺愭哀鍩�-3-鐢插熀涓佽厛
(R)-4-Benzyloxy-3-methylbutyronitrile
98% [ee: 98%]
|
|
1 g
5 g
|
|
Reference:
[1] McKenna, Jeffrey; et al. Assignee Signal Pharmaceuticals, LLC, USA 2007.
[2] Tian, Weisheng; . et. al. Peop. Rep.China 2011
[3] By Zhu, Qiang ; et al.Journal of Organic Chemistry (2001), 66(8), 2692-2699.
[4] Coppel, H. C. et al Science 1976, 192, 51.
[5] Hedenström, E. et al Tetrahedron 1992, 48, 3139.
[6] Wang Z.K. et. al Tetrahedron Lett., 2007, 48, 7549
鈼�鎵嬫�ц紨鍔╁姂
|
鐢�(ch菐n)鍝佺法铏�(h脿o)
|
鐢�(ch菐n)鍝佸悕绋�
|
绲�(ji茅)妲�(g貌u)寮�
|
瑕�(gu墨)鏍�
|
CAS
|
|
|
(R)-(-)-4-Benzyl-3-propionyl-2-
oxazolidinone, 99% ee:99%
|
|
1 g
5 g
|
|
|
|
(S)-4-Benzylthiazolidine-2-thione,
99% ee: 99%
|
|
250 mg
1 g
|
|
|
|
R-tert-Butylsulfinamide, 98%
|
|
1 g
5 g
25 g
|
|
|
|
(R)-(+)-5,5-Diphenyl-4-benzyl-2-
oxazolidinone, 98%, ee:98%
|
|
100 mg 500 mg
1 g
|
|
|
|
(R)-(+)-5,5-Diphenyl-4-methyl-2-
oxazolidinone, 97%
|
|
100 mg 500 mg
|
|
|
|
(4R,5S)-(+)-cis-4,5-Diphenyl-2-
oxazolidinone, 98%, ee:98%
|
|
100 mg 500 mg
|
|
|
|
(R)-(-)-4-(1H-Indol-3-ylmethyl)-2-
oxazolidinone, 98%,ee: 98%
|
|
100 mg 500 mg
|
|
|
|
(S)-(-)-4-Isopropyl-5,5-diphenyl-2-
oxazolidinone, 98%, ee: 99%
|
|
1 g
5 g
|
|
|
|
(S)-(+)-4-Isopropyl-3-propionyl-2-
oxazolidinone, 98%, ee: 98%
|
|
1 g
5 g
|
|